You probably don’t know yet this tool but it’s really cool.
It helps you to make 2D skeleton animations with blending and exports the whole thing for an external use. For an indie, at least, it’s awesome.
I’m doing some testing with the free version and feel like getting the paid one soon.
I’ve been doing my own animations frame by frame till now and believe me it’s cool and painful at the same time. It’s time to go to the next quality level.
Plus : Spine provides some interesting pluggins (including one for Unity).